difference between bohr's effect and haldane's effect!
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Answer:Bohr effect:
Increase in concentration of carbondi-oxide or decrease in pH(i.e..acidic pH) decrease oxygen binding capacity of haemoglobin and induces oxyhaemoglobin to release oxygen to tissues.This phenomenon is called bohr effect.
During inspiration air reaches alveoli of lung,which receives blood of pulmonary circulation . Difference in pressure of o2 and co2 drives exchange of gases between lungs and tissues.
Partial pressure of o2 in alveolar air = 100 mmHg
partial pressure of o2 in venous blood =40 mmHg
As gases diffuses down the concentration gradient,pressure difference of 60 mmHg serves to drive oxygen from lung into blood to tissues
similarly a relatively small difference of 6 mmHg is sufficient to drive co2 from blood to lung because the rate of diffusion of co2 is 20 times faster than that of oxygen.That is
partial pressure of co2 in alveolar air = 40 mmHg
partial pressure of co2 in venous blood = 46 mmHg
By this gases exchange by combine it with haemoglobin. In lungs oxygen binds with haemoglobin and forms oxyhaemoglobin and is transported to tissues and in tissues c02 conc is high as a result of cellular respiration and it combines with water forming carbonic acid(H2CO3) mediated by enzyme carbonic anhydrase which subsequently loses a proton becoming bicarbonate (major blood buffer )
This hydrogen ion protonates histidine residues present in haemoglobin which favours unloading of oxygen to tissues and loading of co2 with haemoglobin and transports to lungs.
This process of delivering oxygen to tissues by decreasing the oxygen binding capacity of haemoglobin by co2 and H+ ions is known as Bohr effect.
After co2 is transported to lungs by haemoglobin,increased conc of o2 in lungs favours oxygen binding with haemoglobin and release co2 .This is known as Haldane effect.
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