Question

Difference between chelate and macrocyclic effect

Answer 1

The macrocyclic effect follows the same principle as the chelate effect, but the effect is further enhanced by the cyclic conformation of the ligand.Macrocyclic ligands are not only multi-dentate, but because they are covalently constrained to their cyclic form, they allow less conformational freedom.

Answer 2

The macrocyclic effect follows the same principle as the chelate effect, but the effect is further enhanced by the cyclic conformation of the ligand.Macrocyclic ligands are not only multi-dentate, but because they are covalently constrained to their cyclic form, they allow less conformational freedom....