Question

Difference between classical and alternative pathway of complement system

Answer 1

The classical complement pathway needs antigen antibody complexes activation. And the alternative complement pathway can be activated by spontaneous complement.

Answer 2

Antigens generated endogenously within these cells are bound to mono hydrocarbon molecules and presented on the cell surface. This antigen presentation pathway enables the immune system to detect transformed or infected cells displaying peptides from modified-self mutated or foreign proteins. Cytosolic proteins are processed primarily by the action of the proteasome. The short peptides are then transported into the ER by TAP for subsequent assembly with MHC-I molecules.