Question

Difference between linear and nonlinear pharmacokinetics

Answer 1

Explanation:

Studying the causes of linear motion is the branch of mechanics known as linear kinetics. Identifying the causes of motion may be the most useful kind of mechanical information for determining what potential changes could be used to improve human movement.

Nonlinear kinetics is usually due to saturation occuring in one of the pharmacokinetic mechanisms: protein binding, hepatic metabolism, or active renal transport of the drug. Saturable elimination: above a certain drug concentration, the elimination rate tends to reach a maximal value.

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Answer 2

Difference between linear and nonlinear pharmacokinetics:

Linear Pharmaco kinetics:

• It doesn't depend on the dosage of the drug that is administrated.
• It is also known as First order kinetics.
• The concentration/amount drug given is proportional to dose.
• The parameters remain unchanged.

Non-linear pharmaco kinetics:

• It depends on the dosage level of the drug that is administrated.
• It is also called as saturated kinetics.
• Drug processing depends on the enzyme molecules of the body.
• When the drug concentration is high, it may result in saturation.
• Parameters are changed.

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