Question

Difference between nanophthalmos and microphthalmia

Answer 1

Warburg (1981, 1993) defined nanophthalmos or pure microphthalmos as a developmental arrest of ocular growth not associated with other ocular malformations. Later, it was underscored that nanophthalmos was a form of total microphthalmos, where both anterior and posterior segments are shortened.

In mammals the failure of expression of the transcription factor, MITF ( microphthalmia-associated transcription factor), in the pigmented retina 

Answer 2

Microphthalmia is a developmental disorder of the eye in which one (unilateral microphthalmia) or both (bilateral microphthalmia) eyes are abnormally small and have anatomic malformations. It is different from nanophthalmos in which the eye is small in size but has no anatomical alterations. . whereas Nanophthalmos. Nanophthalmos is usually characterized by bilateral and symmetrical small eyes, associated with: shortened axial length (20mm or less; at least two standard deviations below age-matched controls), high corneal curvature, high lens/eye volume ratio with narrow iridocorneal angle, high hyperopia