Difference between past and present goblet
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Answer:
Goblet cells are simple columnar goblet shaped like epithelial cells that secrete gel-forming mucins, like mucin MUC5AC.[1] The goblet cells mainly use the merocrine method of secretion, secreting vesicles into a duct, but may use apocrine methods, budding off their secretions, when under stress.[2] The term goblet refers to the cell's goblet-like shape. The apical portion is shaped like a cup, as it is distended by abundant mucus laden granules; its basal portion lacks these granules and is shaped like a stem.
Answer:
Goblet cells are mucous glands - it's just that most mucous glands are multicellular, whereas goblet cells are just the individual cell. They can be found in the epithelial lining of organs, like the respiratory tracts.The main role of goblet cells is to secrete mucus in order to protect the mucous membranes where they are found. Goblet cells accomplish this by secreting mucins, large glycoproteins formed mostly by carbohydrates.The term goblet cell derives from the characteristic wineglass shape of these cells in conventionally fixed tissue: a narrow base and an oval apical portion (expanded with mucin-secreting granules) that sometimes extends into the intestinal lumen.Goblet cells are a requirement for the diagnosis of intestinal metaplasia of the stomach. The gastric mucosa is lined by a monolayer of columnar epithelium with some specialization at the crypts, but there are no goblet cells in normal gastric epithelium.Goblet cells are mostly found scattered in the epithelia of the small intestines and respiratory tract.
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