Difference between pemphigus vulgaris and pemphigus foliaceus
Answers
Answer:
Little is known about differences in epidemiological features and prognosis between pemphigus vulgaris (PV) and pemphigus foliaceus (PF). The objective of this study was to compare PV and PF patients regarding ethnic variations and mortality rates. Mortality of PV and PF patients was compared with age- and sex-matched control subjects in the general population. The study cohort comprised 207 patients with PV and 30 with PF diagnosed during the period 2000 to 2015. The incidence rate of PV among Jews was 3.6-fold higher than among Arabs (p<0.001), whereas no ethnic predisposition to PF was noted (p = 0.379). The risk of death for patients with PV was almost 3-fold higher than in the general population (standardized mortality ratio (SMR) 2.6). For patients with PF, the risk of mortality was not significantly increased relative to the general population (SMR 1.4). There is a racial predisposition to PV, whereas PF is sporadic. Mortality among patients with PV is higher compared with PF and the general population.
Pemphigus vulgaris:
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Patient with PV usually present, in the initial stage, with highly painful erosions of rhe oral mucosa.Skin lesions have a perdilection for the trunk, groins, axillae, scalp, face, and pressure points. Secondary infection and dehydration are frequent cause of morbidity and mortality.
Pemphigus foliaceus:
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Non- endemic PF usually presents in middle age or older adults whereas endemic PF is more common in children and young adults.Pemphigus erythematous is considered to be combination of PF and systemic lupus erythematous typified by the presence of erosions in a malar distribution.
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