Difference between prochirality and prostereoisomerism
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In stereochemistry, prochiral molecules are those that can be converted from achiral to chiral in a single step.[1][2] An achiral species which can be converted to a chiral in two steps is called proprochiral.[2]
If two identical substituents are attached to a sp3-hybridized atom, the descriptors pro-R and pro-S are used to distinguish between the two. Promoting the pro-R substituent to higher priority than the other identical substituent results in an R chirality center at the original sp3-hybridized atom, and analogously for the pro-S substituent.
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