Difference of emulsion absorption orally/ oil and o/ water
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The effect of oil-in-water submicron emulsion (SE) droplet
surface charge on absolute bioavailability of a poorly water-
soluble drug (griseofulvin, as model drug) after oral administration
was studied in conscious rat. Positively, negatively, and neutrally
charged SE were designed and characterized (size, polydispersity
index, zeta potential, and pH). Three emulsion formulations, whose
compositions included 40% oil phase and differed only in the na-
ture of the emulsifying agent, were retained. Only the positively
charged SE showed a higher area under the plasma concentration–
time curve (AUC0→∞) in comparison with the tablet and with the
other ..
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