Question

different between organ specific and tissue specific manifestation

Answer 1

Orgns-specific and tissue-specific manifestations :
Compared to any type of pathogenic microbe, our body is quite large. Thus, there are many possible regions, tissues or organs, where a pathogenic microbe can go and stay. Different species of disease-causing microbes have evolved to move and reach to various parts of the body. In parts, this selection is connected to their point of entry into the body. Few cases are cited below :
If disease-cuasing microbes enter with air via the nose, they are likely to go to the lungs, e.g., bacteria which cause tuberculosis of lungs.
If the pathogenic microorganisms enter via mouth, they are likely to stay in the lining of the gut (e.g., thyphoid-cuasing bacteria) or these pathogens can also go to the liver, e.g., the viruses that cuase jaundice.

Virus that causes HIV infection, enters the body through sexual organs during sexual contact and then tends to spread to lymph nodes throughout the body.
Malaria-causing microbes are transmitted through mosquito bite, and move to the liver and then to the red blood cells (R.B.Cs).
Similarly, virus that causes, Japanese encephalitis (brain fever) enters the body through mosquito bite, However, it will go to reside and infect the brain.

Answer 2

after then you write this=however if microbes is large then the diseases can be serve enough to life threatening...

pls mark braillieast....