Question

Differential effects of oncogenic k-ras and n-ras on proliferation, differentiation and tumor progression in the colon

Answer 1

Furthermore, NRAS and KRAS mutations may have different effects on . KRAS Oncogenic Signaling Extends beyond Cancer Cells

Answer 2

Explanation:

➡️ Kras is commonly mutated in colon cancers, but mutations in Nras are rare. We have used genetically engineered mice to determine whether and how these related oncogenes regulate homeostasis and tumorigenesis in the colon. Expression of K-Ras(G12D) in the colonic epithelium stimulated hyperproliferation in a Mek-dependent manner. N-Ras(G12D) did not alter the growth properties of the epithelium, but was able to confer resistance to apoptosis.