Question

Differentiate ICSI and GIFT​

Answer 1

ICSI is very similar to conventional IVF in that gametes (eggs and sperm) are collected from each partner. Thedifference between the two procedures is the method of achieving fertilisation. In conventional IVF, the eggs and sperm are mixed together in a dish and the sperm fertilises the egg 'naturally'.

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Answer 2

What are the differences between ICSI and GIFT?

Answer:

ICSI is intra-cytoplasmic sperm injection and is basically a way to fertilize an egg with a sperm by directly injecting it into an egg using a micro-pipette. This was invented by a group of Belgian scientists and first birth as a result of ICSI was published in 1992. After ICSI the resulting zygote (or embryo) is made to culture in the laboratory inside an incubator which simulates the intra-uterine environment. Usually the embryo(s) made thereof are transferred inside the uterine cavity (womb) at three or five days of culture inside the incubator.

GIFT on the other hand is gamete intra-fallopian transfer and it involves putting both eggs (single or a few in number) and sperms simultaneously inside the Fallopian tube and not the uterus. Here, it is thought that since both gametes are close to each other they will fertilize on their own and they are not fertilized outside the body. After fertilization the resulting embryo(s) will travel and implant inside the womb at about 5th or 6th day of life, just like it happens in a natural conception.

Both these techniques are a part of ART treatment but GIFT is rarely done nowadays because ICSI has several advantages of visualizing the embryos inside the laboratory and selecting the best embryo(s) possible thereby. Again, ICSI and intra-uterine transfer can be done in those women whose tubes have been blocked whereas GIFT cannot.

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