Question

Dihydroorotate dehydrogenase contains
A.4 flavins and 4 atoms of iron per molecule
B. 2 flavins and 4 atoms of iron per molecule
C. 2 flavins and 2 atoms of iron per molecule
D. 4 flavins and 2 atoms of iron per molecule

Answer 1

Dihydroorotate dehydrogenase (DHODH) is an enzyme that in humans is encoded by the DHODH gene on chromosome 16. The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane(IMM).[1] Inhibitors of this enzyme are used to treat autoimmune diseases such as rheumatoid arthritis.[2]