disadvantages of 3d transformation
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Such signalling cascades are deemed essential for a multitude of cellular processes, including differentiation and proliferation. 9,17,18 In contrast to conventional 2D methods, cells cultured in a 3D format may exhibit unique biochemical and morphologi- cal features similar to their corresponding tissues in vivo 19 (summarized in Table 1). It should be noted that the cell type, as well as the 3D culture method, impacts on cell organiza- tion and formation of the 3D structure. ...
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