Question

discuss how TADs are formed in genome organisation

Answer 1

TADs are megabase-long genomic regions that self-interact, but rarely contact regions outside the domain. They are likely formed and maintained through interactions between CTCF zinc-finger transcription factors and cohesin ring-shaped complexes, among other proteins both known and unknown.

Answer 2

TADs are probably created and supported through connections between CTCF zinc-finger transcriptional regulators.

Explanation:

• A topologically associating domain (TAD) is a self-interacting genomic area in which DNA sequences connect with one another more frequently than sequences outside the TAD.

• They're probably created and supported through connections between CTCF zinc-finger transcriptional regulators and cohesin ring-shaped aggregates, as well as other known and undiscovered proteins.

• In main human blood cell types, the Blueprint collaboration found 2800 to 3741 TADs.