Question

discuss the advantages and disadvantages of the use of retroviruses as a vector

Answer 1

Answer:

Risks and disadvantages of the

Adeno-Associated Virus include integration,

decline in expression over time due

to episomal loss by degradation, small

packaging capacity, low titers, and a

strong immune response. ... The risks

of using the viral vector in gene therapydo

not outweigh the potential benefits

The most important advantage that retroviral

vectors offer is their ability to transform

their single stranded RNA genome into a

double stranded DNA molecule that stably

integrates into the target cell genome. This

means thatretroviral vectors can be used

to permanently modify the host cell nuclear

genome.