discuss the mechanism nucleophilic substitution reaction in pyridine
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Mechanism of nucleophilic substitution in pyridine :
The reactivity of pyridine can be distinguished for three chemical groups. With electrophiles, electrophilic substitution takes place where pyridine expresses aromatic properties. With nucleophiles, pyridine reacts at positions 2 and 4 and thus behaves similar to imines and carbonyls.
Nucleophilc substitution in pyridine favours not only position 2 but also position 4. In order to understand why, we must first draw out the intermediate structures and take a look at the different resonance stabilized forms that it have.
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