Question

Discuss the reason for adjusting ph of the dosage form

Answer 1

the reason for adjusting ph of the dosage form (pH 5.5– 7.5).

 disadvantages of ocular dosage forms .... salt due to the low buffer capacity and lower acidity of this salt 

Answer 2

The reason for adjusting the pH of the dosage form is mainly for drug solubility,activity and absorption.

Explanation:

• pH is the negative logarithm of hydrogen ion concentration.
• It is the measure of acidic or basic water.
• The range of pH is from 0 to 14 where zero to 6 is acidic 7  is neutral and 8 to 14 is basic.
• pH is a measure of the relative amount of hydrogen and hydroxyl ions present in the water
• pH plays an important role in the drug product formulation, mainly in drug solubility, activity, absorption, stability, sorption, and comfort of the patient.

• pH is related to certain physical characteristics such as viscosity of polymers, such as gel-forming agents mainly in suspensions.
• It was also adjusted by using acidifying and alkalizing agents