discuss the signal 1 and Signal 2
Answers
Explanation:
Signal 1 is generated after the interaction of the T cell receptor whereas signal 2 is generated via an interaction between costimulatory molecules on the antigen-presenting cell and counterreceptors on the T cell, such as the well known B7–CD28 interaction.
Signal 1 and 2 during T cell activation. Upon antigen presentation by professional antigen presenting cells (APC), multiple stimulatory molecules control full activation of T cells. Signal 1 is delivered by CD4/CD8 and T cell receptor (TCR)/major histocompatibility (MHC) interaction while signal 2 is delivered by CD28/B7 interaction (or other co-stimulator-receptor pairs) The two signals together are required to induce IL-2 production which will have autocrine and paracrine effects.
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