Question

discuss what endoplasmic reticulum amino peptidase1 ( ERAP1) full lenght WT is. ? (please explain 200 word )​

Answer 1

Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.3 Publications

Caution

It is uncertain whether Met-1 or Met-13 is the initiator.Curated

Cofactori

Zn2+

Note: Binds 1 zinc ion per subunit.

Sites

Feature key Position(s) DescriptionActions Graphical view Length

Binding sitei 183 SubstrateBy similarity  1

Metal bindingi 353 Zinc; catalytic  1

Active sitei 354 Proton acceptorPROSITE-ProRule annotation  1

Metal bindingi 357 Zinc; catalytic  1

Metal bindingi 376 Zinc; catalytic  1

Sitei 438 Transition state stabilizerBy similarity  1

GO - Molecular functioni

aminopeptidase activity Source: UniProtKB

interleukin-1, type II receptor binding Source: HGNC-UCL

interleukin-6 receptor binding Source: UniProtKB

metalloaminopeptidase activity Source: GO_Central

metalloexopeptidase activity Source: UniProtKB

peptide binding Source: GO_Central

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