Discuss what is known about the two nuclear receptor TF families. Compare and contrast the activation of both families [use estrogen and thyroid receptors for examples]. How do their active states impact chromatin? How does the drug "tamoxifen" fit into the estrogen receptor positive breast cancer treatment?
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once activated by estrogen, the ER is able to translocate into the nucleus and bind to DNA to regulate the activity of different genes (i.e. it is a DNA-binding transcription factor). However, it also has additional functions independent of DNA binding.
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