Do a case study on effect of medicines used during Covid -nineteen for positive patients and negative patients
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To increase the success in Covid 19 treatment, many drug suggestions are presented, and some clinical studies are shared in the literature. There have been some attempts to use some of these drugs in combination. However, using more than one drug together may cause serious side effects on patients. Therefore, detecting drug-drug interactions of the drugs used will be of great importance in the treatment of Covid 19. In this study, the interactions of 8 drugs used for Covid 19 treatment with 645 different drugs and possible side effects estimates have been produced using Graph Convolutional Networks. As a result of the experiments, it has been found that the hematopoietic system and the cardiovascular system are exposed to more side effects than other organs. Among the focused drugs, Heparin and Atazanavir appear to cause more adverse reactions than other drugs. In addition, as it is known that some of these 8 drugs are used together in Covid-19 treatment, the side effects caused by using these drugs together are shared. With the experimental results obtained, it is aimed to facilitate the selection of the drugs and increase the success of Covid 19 treatment according to the targeted patient.
Introduction
As of December 2019, a coronavirus species that can spread from person to person was identified in Wuhan, China1. The disease later on called Covid-19 posed a risk to be declared as a pandemic by the World Health Organization (WHO) in a short time2. As of the date of this study in early June 2020, more than 6.4 million people were infected with this virus, and 373,334 persons died. It has been realized that scientists and researchers have published thousands of clinical trial results and articles in this process to provide treatment methods for the disease3. An important part of these studies examines the use of existing drugs for Covid-19 treatment, and suggests possible treatment methods4,5,6.
One of the issues that should be examined before recommending a drug to a patient and after treatment is the side effects of the drug. Research shows that multiple drugs usage (polypharmacy) significantly increases drug side effects7,8. For older patients, the probability of polypharmacy generally increases. However, studies clearly show that as the number of drugs used increases, the negative effects seen in patients may also increase9,10,11. Therefore, it is vital to predict drug-drug interactions (DDI) and adverse drug reactions (ADR) for the drugs to be used in the treatment of a disease8,12. Knowing the side effects and DDI of the drugs recommended in Covid-19 treatment will play an importa
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