Question

Do heterodimer protein interacts with gene directly or indirectly

Answer 1

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Question ) Do heterodimer protein interacts with gene directly or indirectly.

Answer )

Neither protein can partition to the native state or assemble into polymerization

Discharge of the native α/β heterodimer occurs via interaction .

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Answer 2

Explanation:

–KOR in Spinal Analgesia

Opioid receptor heterodimers appear to playa role in the modulation of analgesic responses. The existance of the DOR–KOR heterodimer in vivo has been demonstrated indirectly by the binding of DOR–KOR specific ligands in select regions of the nervous system, such as the spinal cord [80]. In agreement with this, DOR–KOR heterodimers have been shown to be involved in spinal analgesia. The heterodimer specific agonist 6′-GNTI elicits analgesia when administered directly into the spinal cord, but has no effect when administered directly to the brain [46]. This supports the notion that the heterodimers are likely to represent a tissue-specific target. Moreover, this spinal-selective analgesic effect was blocked by a bivalent DOR–KOR selective receptor antagonist, confirming the involvment of the DOR–KOR heterodimer in modulation of pain/analgesia and supporting the possibility that this heterodimer represents a functional target for analgesia in vivo