Drug release and dissolution is same under what circumstances
Answers
Drug release refers to the process by which the drug loaded in or on the NMs is released in the body through diffusion or dissolution of the NMs matrix releasing the drug in solution. Biodegradation refers to the process by which the drug delivery system is broken down inside the body. Both drug release and biodegradation are important to consider when developing an NMs drug delivery system. Ordinarily, effectiveness of drugs is dependent not only on its active components but also on its solubility and diffusion. When the drug is delivered using an NMs delivery system, effectiveness is affected by parameters such as the particle size, release process which is in turn affected by the biodegradation of the particle matrix. The smaller the particles, the larger the surface area-to-volume ratio; therefore, most of the drug associated with small particles would be at or near the particle surface which leads to faster drug release. In contrast, larger particles have large cores, which allow more drugs to be encapsulated per particle and give slower release. Thus, control of particle size provides a means of tuning drug release rates.