Question

DU
Residencia
Question 32
? Which of the following is a
type A (augmented) adverse
drug reaction?
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Answer 1

Answer:

Type A reactions (pharmacological/augmented) result from an exaggeration of a drug's normal pharmacological actions when given at the usual therapeutic dose. They are dose dependent and are therefore readily reversible on reducing the dose of (or withdrawing treatment with) the drug.An adverse drug event (ADE) is an injury resulting from medical intervention related to a drug. This includes medication errors, adverse drug reactions, allergic reactions, and overdoses. ADEs can happen anywhere: in hospitals, long-term care settings, and outpatient settings.Drawing from Nebeker, Barach, & Samore (2004): “Adverse drug events refer to harm caused by appropriate or inappropriate use of a drug whereas adverse drug reactions are a subset of these events, where harm is directly caused by a drug under appropriate use (i.e. at normal doses)Type B reactions are idiosyncratic, bizarre or novel responses that cannot be predicted from the known pharmacology of a drug and are associated with low morbidity and high mortality. Not all ADRs fit into type A and type B categories; therefore, additional categories have been developed.Type B reactions are idiosyncratic, bizarre or novel responses that cannot be predicted from the known pharmacology of a drug and are associated with low morbidity and high mortality. Not all ADRs fit into type A and type B categories; therefore, additional categories have been developed.Type C: Dose and time-related reactions, eg due to dose accumulation, or with prolonged use (eg. adrenal suppression with corticosteroids) Type D: Time related reactions, i.e. due to prolonged use in a drug which doesn't tend to accumulate (eg.Idiosyncratic reactions are unpredictable and not explained by the pharmacologic properties of the drug. An example is the individual with infectious mononucleosis who develops a rash when given ampicillin.