During the preparation of trace metals and air sensitive formulation which adjuvant is used to prepare
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Answer:
Trace metal analysis identifies and quantifies very small amounts of metals and heavy metals in a sample. Although having some trace metals in our diet is essential for our well-being, many metals can be toxic and can negatively impact human, animal and plant health, as well the environment. Trace metal analysis is used to ensure compliance with legal requirements and regulations. In pharmaceutical, chemical and petrochemical industries, trace metal analysis is used in quality control to identify and measure metal contaminants in products such as drugs, fertilizers, cosmetics, packaging, medical devices, lubricants and catalysts. Due to the influence metals may have on different chemical reactions, trace metal analysis is also used in chemical formulation research and for improving manufacturing processes.
Determining very small quantities of potentially toxic elemental impurities such as lead (Pb), mercury (Hg), arsenic (As), cadmium (Cd), copper (Cu), nickel (Ni), zinc (Zn) etc. requires highly sensitive analytical equipment. The metals in a sample are typically measured in parts per million (ppm), parts per billion (ppb) or even parts per trillion (ppt), depending on the complexity of the sample (i.e. the sample matrix) and the analytical technique used. Common analytical methods used for trace metal analysis include atomic absorption spectroscopy (AAS), inductively coupled plasma optical emission spectroscopy (ICP-OES) and inductively coupled plasma mass spectrometry (ICP-MS).
Why Accurate Weighing Is Important
Trace metal analysis requires precisely and accurately prepared samples, reference standards and calibration standards to ensure accurate and valid results. Sample and standard preparation errors can account for the largest source of errors in the whole trace metal analysis workflow. The balance used must meet the accuracy requirements of the application. The balance capacity and minimum weight are essential criteria for selection of the appropriate balance. Determining the safe weighing range of the balance is also of utmost importance to ensure the validity of the weighing results.
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Typical workflow for trace metal analysis
Know-How: Application and standard test methods for metal elemental analysis in various industries and workplaces
- Pharmaceutical industry
- Food & agriculture
- Environment
- Petroleum and chemicals
Analytical instrument for trace metal analysis: Decision criteria
How to select the correct weighing device
Request free support on weighing samples and standards for trace metal analysis
The challenges of trace metal analysis
METTLER TOLEDO featured solution for standard preparation in trace metal analysis
Watch the video: Trace metal analysis – preparation of high-purity stock standard
Download the free weighing guide: Safe weighing explained
METTLER TOLEDO solution for semi-automated reference standard preparation
FAQs - frequently asked questions on trace metal analysis