Question

Dysregulation of the nudt7-pgam1 axis is responsible for chondrocyte death during osteoarthritis pathogenesis

Answer 1

Abstract

Osteoarthritis (OA) is the most common degenerative joint disease; however, its etiopathogenesis is not completely understood. Here we show a role for NUDT7 in OA pathogenesis. Knockdown of NUDT7 in normal human chondrocytes results in the disruption of lipid homeostasis. Moreover, Nudt7−/− mice display significant accumulation of lipids via peroxisomal dysfunction, upregulation of IL-1β expression, and stimulation of apoptotic death of chondrocytes. Our genome-wide analysis reveals that NUDT7knockout affects the glycolytic pathway, and we identify Pgam1 as a significantly altered gene. Consistent with the resul