Question

Earliest evidence that a drug is stored in tissue is

Answer 1

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Answer 2

Answer:

Earliest evidence that a drug is stored in tissue is a large apparent volume of distribution (VD).

Explanation:

A large apparent volume of distribution is the earliest indication that a drug is stored in tissue (VD). A higher dose of a drug is necessary to reach a given plasma concentration for a substance with a high Vd because such substances are more likely to leave the plasma and enter the extravascular compartments of the body. Higher distribution to other tissues (High Vd) The hypothetical fluid volume through which a drug is dispersed is known as the apparent volume of distribution (Vd) for that particular drug. It is calculated by dividing the total dosage given by the plasma drug concentration.

• The degree of plasma protein and tissue binding determines how much of a drug is distributed into the tissues.
• Drugs are partially transported in solution as free (unbound) drugs and partially reversibly bound to blood components in the bloodstream (eg, plasma proteins, blood cells). rate of glomerular filtration (GFR).
• An increase in plasma protein binding is the earliest indication that a drug is being stored in tissue.