Question

Effect of antibody mediated graft rejection

Answer 1

Most insights into processes of antibody-mediated rejection of kidney grafts have come from carefully designed clinical studies. However, several new mouse models of antibody-mediated kidney allograft rejection may replicate the pathologies observed in clinical kidney grafts and may be useful in directly testing mechanisms that underlie acute and chronic antibody-mediated graft injury.

Answer 2

Non-HLA Antibody-Mediated Rejection :

Non-HLA antibodies comprise an evolving field in transplant immunology. These antibodies were associated with an increased risk of allograft loss, an increased rate of AMR, and a more severe graft injury phenotype with increased microcirculatory inflammation and more C4d deposition.