Question

Efficacy of fexofenadine versus desloratadine in suppressing histamine-induced wheal and flare

Answer 1

This study was done on 30 healthy volunteers (18-50 years of age) after obtaining their informed consent. The volunteers were not taking any antihistamines, steroids or immunosuppressants for seven days prior to the study. None of them had any history of atopy, drug hypersensitivity or use of alcohol. Pregnant and lactating women were excluded.

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cRAZY pRINCE

Answer 2

The primary end point was change in size of histamine-induced summation skin flares. ... Fexofenadine HCl, 180 mg, was superior to desloratadine, 5 mg, in histamine-induced wheal-and-flare suppression, suggesting increased in vivo H1-receptor antagonist potency of fexofenadine versus desloratadine.