Question

Enzyme inhibition and describe the different types of reversible inhibition

Answer 1

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Enzyme inhibitors are molecules or compounds that bind to enzymes and result in a decrease in their activity. An inhibitor can bind to an enzyme and stop a substrate from entering the enzyme's active site and/or prevent the enzyme from catalyzing a chemical reaction. There are two categories of inhibitors.

irreversible inhibitors

reversible inhibitors...

Examples of reversible inhibition:

competitive inhibition (Raises Km only)

uncompetitive inhibition (Lowers Vmax and Km)

noncompetitive inhibition (Lowers Vmax only)

Examples of irreversible inhibition:

group specific: reacts only to certain chemical group.

reactive substrate analogs (affinity label): inhibitor that are structurally similar to the substrate and will bind to active site.

mechanism-based inhibitors (suicide inhibitors): enzymes converts the inhibitor into a reactive form within active site.....

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