Question

enzyme which is responsible for itch in humans​

Answer 1

Proteases. Endogenous serine proteases such as trypsin and tryptase evoke itch in humans [89–92]. Similarly, injection of trypsin, tryptase, and other proteases in experimental animals evokes scratching behaviour [93–95]. Endogenous proteases are upregulated in human skin with atopic dermatitis [91, 96].

Answer 2

Answer:

Cathepsin S is a lysosomal enzyme

responsible for itching in humans.