Enzymes assay for human blood plasma in
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Human plasma fraction IV-1 contains an enzyme that rapidly inactivates bradykinin and kallidin II. The activity of the enzyme was characterized with biological and chemical techniques; it inactivates bradykinin by breaking its Phe8.Arg9 bond.Zn2+ or Co2+ can reactivate the enzyme, which is inhibited by chelating agents, but Co2+ is the only accelerator found. Numerous other compounds inhibit only. The enzyme in human red blood cells that destroys bradykinin is different from the plasma enzyme. The suggestion was made to name the enzyme in human plasma fraction IV-1 “carboxypeptidase N”.
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