Epithelial cells shows overcrowiding and overlapping of nuclei with loss og alignment and polarity
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Epithelial Cell Polarity
Many tissues are lined by epithelia with apical cell membranes facing the lumen, polarization allows epithelial cells to transport molecules across the surface in a directional manner.
Cell polarity refers to the intrinsic asymmetry observed in cells, either in their shape, structure, or organization of cellular components. Epithelial cells become polarized along the apical-basal axis. The apical membrane faces the lumen and is rich in PAR and Crumbs protein complexes.
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