Epithelial-to-mesenchymal transition and cancer stem(-like) cells in head and neck squamous cell carcinoma
Answers
Answered by
0
Head and neck squamous cell carcinoma (HNSCC) is the 6th commonest cancer worldwide. Relapse, thought to involve cancer stem(-like) cells (CSCs), and the development of metastases are common and survival rates remain low. Epithelial-to-mesenchymal transition (EMT) is a key event in metastasis and increasing evidence suggests a link between EMT and CSCs. MicroRNAs regulate multiple cellular processes including EMT and have been implicated in a CSC phenotype. This review aims to highlight key events that are involved in EMT, discusses their relevance in HNSCC progression and metastasis and explores the possibility of targeting EMT as a novel therapy in HNSCC.
Answered by
3
Explanation:
Carcinoma is a type of cancer that starts in cells that make up the skin or the tissue lining organs, such as the liver or kidneys. Like other types of cancer, carcinomas are abnormal cells that divide without control. They are able to spread to other parts of the body, but don't always.
Similar questions