Evaluation of microbial stability of formulation
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Filippos Kesisoglou, Santipharp Panmai, Yunhui Wu
Advanced drug delivery reviews 59 (7), 631-644, 2007
Poor aqueous solubility represents a major hurdle in achieving adequate oral bioavailability for a large percentage of drug compounds in drug development nowadays. Nanosizing refers to the reduction of the active pharmaceutical ingredient (API) particle size down to the sub-micron range, with the final particle size typically being 100–200 nm. The reduction of particle size leads to a significant increase in the dissolution rate of the API, which in turn can lead to substantial increases in bioavailability. This review describes the principles behind …
Advanced drug delivery reviews 59 (7), 631-644, 2007
Poor aqueous solubility represents a major hurdle in achieving adequate oral bioavailability for a large percentage of drug compounds in drug development nowadays. Nanosizing refers to the reduction of the active pharmaceutical ingredient (API) particle size down to the sub-micron range, with the final particle size typically being 100–200 nm. The reduction of particle size leads to a significant increase in the dissolution rate of the API, which in turn can lead to substantial increases in bioavailability. This review describes the principles behind …
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One way is to look at our instantaneous velocity, represented by one point on our curvy line of motion graphed with distance vs. time. ... The velocity of an object at any given moment is the slope of the tangent line through the relevant point on its x vs. t graph
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