example of alkylating derivative
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Cyclophosphamide. Cyclophosphamide, an alkylating agent, is a nitrogen mustard derivative (Fig. ... Phosphoramide mustard covalently binds to guanine in DNA, destroying the purine ring and preventing cell replication.
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Cyclophosphamide. Cyclophosphamide, an alkylating agent, is a nitrogen mustard derivative (Fig. ... Phosphoramide mustard covalently binds to guanine in DNA, destroying the purine ring and preventing cell replication.
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Four methylating alkylating agents are in clinical use. These include procarbazine, DTIC, streptozotocin, and temozolomide. Procarbazine and DTIC are triazines. Streptozotocin is a monofunctional methyl nitrosourea derivative with an attached sugar moiety, and temozolomide is an imidazotetrazine.
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