Exanples of Drug synergy and Drug Antagonism
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Examples include intrathecal or epidural opioids combined with intravenous, intramuscular, oral, transdermal, or subcutaneous analgesics versus intrathecal or epidural opioids alone. Another example is intravenous opioids combined with oral NSAIDs, COX-2 inhibitors, or acetaminophen versus intravenous opioids alone.
There are two types of antagonism: competitive (reversible, surmountable) and non-competitive (irreversible, insurmountable). For example, naloxone is a competitive antagonists at all opioid receptors and ketamine is a non-competitive antagonist at the NMDA-glutamate receptor.
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