Question

Explain about Alpha-2 Macroglobulin.​

Answer 1

Alpha 2 macroglobulin acts as an antiprotease and is able to inactivate an enormous variety of proteinases. It functions as an inhibitor of fibrinolysis by inhibiting plasmin and kallikrein. It functions as an inhibitor of coagulation by inhibiting thrombin.

Answer 2

Alpha-2 macroglobulin is a tetrameric protein with molecular weight of 725kD. It's the major component of alpha-2 globulins. It is synthesized by hepatocytes and macrophages. AMG inactivates all proteases, and is an important in vivo anticoagulant.AMG is the carrier of many growth factors such as platelet derived growth factor (PDGF).