Explain acylation of amines
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the free encyclopedia. Amine alkylation (amino-de-halogenation) is a type of organic reaction between an alkyl halide and ammonia or an amine. The reaction is called nucleophilic aliphatic substitution (of the halide), and the reaction product is a higher substituted amine.
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ɪɴ ᴄʜᴇᴍɪsᴛʀʏ, ᴀᴄʏʟᴀᴛɪᴏɴ (ᴏʀ ᴀʟᴋᴀɴᴏʏʟᴀᴛɪᴏɴ) ɪs ᴛʜᴇ ᴘʀᴏᴄᴇss ᴏғ ᴀᴅᴅɪɴɢ ᴀɴ ᴀᴄʏʟ ɢʀᴏᴜᴘ ᴛᴏ ᴀ ᴄᴏᴍᴘᴏᴜɴᴅ. ... ᴀʟʟ ʀᴇᴀᴄᴛ ᴡɪᴛʜ ᴀᴍɪɴᴇs ᴛᴏ ғᴏʀᴍ ᴀᴍɪᴅᴇs ᴀɴᴅ ᴀʟᴄᴏʜᴏʟs ᴛᴏ ғᴏʀᴍ ᴇsᴛᴇʀs ʙʏ ɴᴜᴄʟᴇᴏᴘʜɪʟɪᴄ ᴀᴄʏʟ sᴜʙsᴛɪᴛᴜᴛɪᴏɴ. ᴀᴄʏʟᴀᴛɪᴏɴ ᴄᴀɴ ʙᴇ ᴜsᴇᴅ ᴛᴏ ᴘʀᴇᴠᴇɴᴛ ʀᴇᴀʀʀᴀɴɢᴇᴍᴇɴᴛ ʀᴇᴀᴄᴛɪᴏɴs ᴛʜᴀᴛ ᴡᴏᴜʟᴅ ɴᴏʀᴍᴀʟʟʏ ᴏᴄᴄᴜʀ ɪɴ ᴀʟᴋʏʟᴀᴛɪᴏɴ.
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