Question

Explain carbylamine reaction with suitable example. Explain the formation of peptide bond?

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Answer 1

Q.1:Explain carbylamine recation with suitable example?

Ans:The carbylamine reaction, also known as Hofmann's isocyanide test is a chemical test for the detection of primary amines. In this reaction, the analyte is heated with alcoholic potassium hydroxide and chloroform. If a primary amine is present, the isocyanide (carbylamine) is formed which are foul smelling substances.

Q.2: Explain the formation of peptide bond?

Ans:A peptide bond is a chemical bond formed between two molecules when the carboxyl group of one molecule reacts with the amino group of the other molecule, releasing a molecule of water (H2O). This is a dehydration synthesis reaction (also known as a condensation reaction), and usually occurs between amino acids.

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Answer 2

Question :

Explain carbylamine reaction with suitable example. Explain the formation of peptide bond?

Answer :

Explaining the carylamine reaction with example :-

• The carbylamine reaction (also known as the Hoffmann isocyanide synthesis) is the synthesis of an isocyanide by the reaction of a primary amine, chloroform, and base.

• The conversion involves the intermediacy of dichlorocarbene. Illustrative is the synthesis of tert-butyl isocyanide from tert-butylamine in the presence of catalytic amount of the phase transfer catalyst chloride.

Me₃CNH₂ + CHCl₃ + 3 NaOH → Me₃CNC + 3 NaCl + 3 H₂O

Example :

Aliphatic or aromatic primary amines on heating with chloroform give foul (offensive) smelling products called isocyanides or carbylamines.

Now, Explaining the formation of peptide bond :-

• A peptide bond is a chemical bond formed between two molecules when the carboxyl group of one molecule reacts with the amino group of the other molecule, releasing a molecule of water (H₂O).

• This is a dehydration synthesis reaction (also known as a condensation reaction), and usually occurs between amino acids.

• The resulting CO-NH bond is called a peptide bond, and the resulting molecule is an amide.

• The four-atom functional group -C(=O)NH- is called an amide group or (in the context of proteins) a peptide group.

• Polypeptides and proteins are chains of amino acids held together by peptide bonds, as is the backbone of PNA.