Question

Explain competitive enzyme inhibition giving an example.

Answer 1

ANSWER

In competitive inhibition, an inhibitor that resembles the normal substrate binds to the enzyme, usually at the active site, and prevents the substrate from binding. ... Competitive inhibitors are commonly used to make pharmaceuticals. For example, methotrexate is a chemotherapy drug that acts as a competitive inhibitor.

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Answer 2

An example of competitive inhibition was demonstrated experimentally for the enzyme succinic dehydrogenase, which catalyzes the oxidation of succinate to fumarate in the Krebs cycle. Malonate binds to the active site of succinic dehydrogenase so that succinate cannot. Thus, it inhibits the reaction.