Explain factors affecting immunogenicity with examples.
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If the substance is soluble in body fluids there is a possibility of exposure of hidden epitopes to induce immune response. For example pneumococcal polysaccharides are greater immunogens in mice but not in rabbits, because the pneumococal molecules are highly soluble in mice body fluids but not in rabbits.
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Antigen and Factors Affecting Immunogenicity. The substance that induce a specific immune response and subsequently react with the products of a specific immune response is called antigen (it is more appropriately called as immunogen).
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