Explain Forbidden Clones?
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More than 60 years ago, Burnet first proposed the 'forbidden clone' hypothesis postulating that autoimmune disease arises as a result of persistence of self-reactive clones of lymphocytes that should have been deleted via immune tolerance
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Clones refer to producing genetically identical individuals. Forbidden clones refer to clones of those cells which has immunological reactivity with self antigens. Embryonic life is eliminated from these types of clones. Such type of clones is called ‘forbidden clones’.
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