Explain functions of topoisomerase1 and 2 and gyrases
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Type I topoisomerases are enzymes that cut one of the two strands of double-stranded DNA, relax the strand, and reanneal the strand. They are further subdivided into two structurally and mechanistically distinct topoisomerases: type IA and type IB.
Type II topoisomerases cut both strands of the DNA helix simultaneously in order to manage DNA tangles and supercoils
DNA gyrase: structure and function. ... DNA gyrase is an essential bacterial enzyme that catalyzes the ATP-dependent negative super-coiling of double-stranded closed-circular DNA. Gyrase belongs to a class of enzymes known as topoisomerases that are involved in the control of topological transitions of DNA.
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