explain Gabriel phthalimide synthesis with example.
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Answer:
The reaction of phthalimide with ethanolic KOH gives potassium salt of phthalimide. It is then heated with alkyl halide to form N-alkyl phthalimide. Aromatic primary amines cannot be prepared as aryl halides do not undergo nucleophilic substitution with anion formed by phthalimide. ...
Explanation:
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Answer:
Gabriel Phthalimide Synthesis Mechanism has 3 steps. The Synthesis is used to get primary amines from primary alkyl halides and is named after the German scientist Siegmund Gabriel.
The reaction has been generalized for applications in the alkylation of sulfonamides and imides & their deprotection in order to obtain amines. Alkylation of ammonia is quite inefficient, therefore it is substituted with phthalimide anion in the Gabriel synthesis