explain how nondisjunction can lead to aneuplodies
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There are three forms of nondisjunction: failure of a pair of homologous chromosomes to separate in meiosis I, failure of sister chromatids to separate during meiosis II, and failure of sister chromatids to separate during mitosis. Nondisjunction results in daughter cells with abnormal chromosome numbers (aneuploidy).
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Aneuploidy is caused by nondisjunction, which occurs when pairs of homologous chromosomes or sister chromatids fail to separate during meiosis. If homologous chromosomes fail to separate during meiosis I, the result is no gametes with the normal number (one) of chromosomes.
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