Question

explain lock and key hypothesis of enzyme action

Answer 1

this hypothesis was explained by Emil fischer

active site of enzyme(lock) will be activated only when a particular and suitable substrate (key) acts on that lock

substrate is converted to products that no longer fit the active site and are therefore released, liberating the enzyme

Answer 2

Given by Emil Fischer. Both enzyme and substrate molecule will have same geometrical shape. similar to lock and key system. This active site contain NH2,COOH, SHE for binding with the substrate molecule. Like a lock can be opened by a specific key,a substrate molecule can be acted upon by a particular enzyme. After coming in contact the substrate molecule form a complex called enzyme substrate complex. In this complex the molecule of substrate undergo change and form product. The product no longer fit into the active site and escape in to the surrounding medium leaving the active site free to receive more substrate molecules.