Question

Explain protein tertiary structure prediction by homology modelling.

Answer 1

Answer:

The method of homology modeling is based on the observation that protein tertiary structure is better conserved than amino acid sequence. Thus, even proteins that have diverged appreciably in sequence but still share detectable similarity will also share common structural properties, particularly the overall fold

Answer 2

Explanation:

Tertiary structure:

• The long protein chain of the

polypeptide chain usually folds

upon itself like a hollow woollen

ball. This is termed as tertiary

structure. This structure gives a

3-dimensional view of protein.

• Tertiary structure is absolutely

necessary for the many

biological activities of proteins

for example, this structure

brings distant amino acid side

chains closer forming the active

site (the site to which a

substrate gets attached) of

proteins i.e., enzymes. e.g.,

Myoglobin (protein found in

muscle cell)