explain the factor on which toxicity of a substance depend on
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The toxicity of a substance usually depends on the following factors:
● Form and innate chemical activity
● Dosage, especially dose-time relationship
● Exposure route
● Species
● Life stage, such as infant, young adult, or elderly adult
● Gender
● Ability to be absorbed
● Metabolism
● Distribution within the body
● Excretion
● Health of the individual, including organ function and pregnancy, which involves physiological changes that could influence toxicity
● Nutritional status
● Presence of other chemicals
● Circadian rhythms (the time of day a drug or other substance is administered)
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